Publications (* co-first author; # co-corresponding author)
2017
Zhang, L., Mazo-Vargas, A. & Reed R.
A single master regulatory gene coordinates the evolution and development of butterfly color and iridescence.
Proceedings of the National Academy of Sciences Cover Article
Mazo-Vargas, A., C. Concha, L. Livraghi, D. Massardo, R. Wallbank, L. Zhang, J. Papador, D. Martinez-Najera, M.R. Kronforst, C.J. Breuker, R. Reed, N.H. Patel, W.O. McMillan, A. Martin.
Macroevolutionary shifts of WntA function potentiate butterfly wing-pattern diversity.
Proceedings of the National Academy of Sciences
Zhang, L.#, Martin, A., Perry, M., van der Burg, K., Matsuoka, Y., Monteiro A.# & Reed R.#
Genetic Basis of melanin pigmentation in butterfly wings.
Genetics, 205(4):1537-1550. Cover Article
Zhang, L., Reed R.
A practical guide to CRISPR/Cas9 genome editing in Lepidoptera.
In Diversity and Evolution of Butterfly Wing Patterns
Li Y., Zhang L., Qu T., Tang X., Li L. & Zhang G.
Conservation and divergence of mitochondrial apoptosis pathway in the Pacific oyster, Crassostrea gigas.
Cell death & disease, 8(7):e2915.
Huang, B*., Zhang, L.*, Du, X., Xu, F., Li, L. & Zhang, G.
Characterization of the Mollusc RIG-I/MAVS Pathway Reveals an Archaic Antiviral Signaling Framework in Invertebrates.
Scientific reports, 7:8217. PubMed
2016
Zhang, L. & Reed R.D.
Key roles for spalt and Distal-less in butterfly eyespot development revealed by CRISPR/Cas9 genome editing.
Nature Communications, 7, 11769. Ncomms
Media coverage: Science News, Science Daily, EurkAlt, Newswise, Technology.org, Health Medicinet, Cornell Chronicle, Gazeta.ru, NU
Huang, B.*, Zhang, L.*, Tang, X., Zhang, G., & Li, L.
Genome-wide analysis of alternative splicing provides insights into stress adaptation of the Pacific oyster.
Marine Biotechnology, 18(5):598-609. Springer
Tang, X., Huang, B., Zhang, L., Li, L., & Zhang, G.
TANK-binding kinase-1 broadly affects oyster immune reponse to bacteria and viruses.
Fish & Shellfish Immunology, 56, 330-335. PubMed
Zhu, Q., Zhang, L., Li, L., Que, H., & Zhang, G.
Expression characterization of stress genes under high and low temperature stresses in the Pacific oyster, Crassostrea gigas.
Marine Biotechnology, 18(2), 176-188. PubMed
Li, Y., Zhang, L., Qu, T., Li, L., & Zhang, G.
Characterization of oyster woltage-dependent anion channel 2 (VDAC2) suggests its involvement in apoptosis and host defense.
PloS one, 11(1), e0146049. PubMed
Huang, B., Zhang, L., Du, Y., Li, L., Tang, X., & Zhang, G.
Molecular characterization and functional analysis of tumor necrosis factor receptor-associated factor 2 in the Pacific oyster.
Fish & Shellfish Immunology, 48, 12-19. PubMed
Zhang, G., Li, L., Meng, J., Qi, H., Qu, T., Xu, F., & Zhang, L.
Molecular basis for adaptation of oysters to stressful marine intertidal environments.
Annual review of animal biosciences, 4, 357-381. PubMed
2015
Meng, J., Zhang, L., Li, L., Li, C., Wang, T., & Zhang, G.
Transcription factor CgMTF-1 regulates CgZnT1 and CgMT expression in Pacific oyster (Crassostrea gigas) under zinc stress.
Aquatic Toxicology, 165,179-188. PubMed
Guo, X., He, Y., Zhang, L., Lelong, C., & Jouaux, A.
Immune and stress response in oysters with insights on adaptation.
Fish & Shellfish immunology, 46(1), 107-119. PubMed
Zhang, L., Li, L., Guo, X., Litman, G. W., Dishaw, L. J., & Zhang, G.
Massive expansion and functional divergence of innate immune genes in a protostome.
Scientific Reports, 5, 8693. PubMed
100 topcited, 2015
Huang, B., Zhang, L., Li, L., Tang, X., & Zhang, G.
Highly diverse fibrinogen-related proteins in the Pacific oyster Crassostrea gigas.
Fish & Shellfish immunology, 43(2), 485-490. PubMed
Qu, T.*, Zhang, L.*, Wang, W., Huang, B., Li, Y., Zhu, Q., & Zhang, G.
Characterization of an inhibitor of apoptosis protein in Crassostrea gigas clarifies its role in apoptosis and immune defense.
Developmental & Comparative Immunology, 51(1), 74-78. PubMed
Meng, J., Zhang, L., Huang, B., Li, L., & Zhang, G.
Comparative analysis of oyster (Crassostrea gigas) immune responses under challenge by different Vibrio strains and conditions.
Molluscan Research, 35(1), 1-11. MR
2014
Zhang, L., Li, L., Zhu, Y., Zhang, G., & Guo, X.
Transcriptome analysis reveals a rich gene set related to innate immunity in the eastern oyster (Crassostrea virginica).
Marine Biotechnology, 16(1),17-33. PubMed
Wang, X., Li, Q., Lian, J., Li, L., Jin, L., Cai, H., Xu F., Qi H., Zhang L.,... & Zhang, G.
Genome-wide and single-base resolution DNA methylomes of the Pacific oyster Crassostrea gigas provide insight into the evolution of invertebrate CpG methylation.
BMC genomics, 15(1), 1119. PubMed
Huang, B., Zhang, L., Du, Y., Li, L., Qu, T., Meng, J., & Zhang, G.
Alternative splicing and immune response of Crassostrea gigas tumor necrosis factor receptor-associated factor 3.
Molecular biology reports, 41(10), 6481-6491. PubMed
Qu, T, Huang, B, Zhang, L., Li, L., Xu, F., Huang, W., Li, C., Du, Y., Zhang, G.
Identification of functional characterization of two executioner caspases in Crassostrea gigas.
PloS one, 9(2),e89040. PubMed
2013
Zhang, L., Li, L., Xu, F., Qi, H., Wang, X. & Zhang, G
Fosmid library construction and microsatellite analysis of the Pacific oyster, Crassostrea gigas.
Molluscan Research, 33(1),65-73. MR
Du, Y., Zhang, L., Xu, F., Huang, B., Li, L. & Zhang, G.
Validation of housekeeping genes as internal controls for studying gene expression during Pacific oyster (Crassostrea gigas) development by quantitative real-time PCR.
Fish & Shellfish Immunology, 34(3),939-945. PubMed
Du, Y., Zhang, L., Huang, B., Li, L. & Zhang, G.
Molecular cloning, characterization and expression of two MyD88s in Pacific oyster (Crassostrea gigas).
Journal of the World Aquaculture society, 44(6), 759-774. Wiley
Meng, J., Zhu, Q., Zhang, L., Li, C., Li, L., She, Z., & Zhang, G.
Genome and transcriptome analyses provide insight into the euryhaline adaptation mechanism of Crassostrea gigas.
PloS one, 8(3), e58563. PubMed
2012
Zhang, G. *, Fang, X. *, Guo, X. *, Li, L. *, Luo, R. *, Xu, F. *, Yang, P. *, Zhang, L. *, Wang, X. *, Qi, H., Xiong, Z., et al.
The oyster genome reveals stress adaptation and complexity of shell formation.
Nature, 490 (7418), 49-54. (* co-first author) Nature
Media coverage: Washington Post, Science News, BBC News, Science Daily, Scientific American, Fox News, Yahoo News
Zhang, L., Li, L. & Zhang, G.
Sequence variability of fibrinogen-related proteins (FREPs) in the Crassostrea gigas.
Chinese Science Bulletin, 57 (25), 3312-3319. Springer
2011
Zhang, L., Li, L. & Zhang, G.
A Crassostrea gigas Toll-like receptor and comparative analysis of TLR pathway in invertebrates.
Fish & Shellfish Immunology, 30, 653-60. PubMed
Zhang, L., Li, L. & Zhang, G.
Gene discovery, comparative analysis and expression profile reveal the complexity of the Crassostrea gigas apoptosis system. Developmental & Comparative Immunology, 35: 603-610. PubMed
Zhang, L., Li, L. & Zhang, G.
The first identification of molluscan Ecsit in the Pacific oyster, Crassostrea gigas, and its expression against bacterial challenge
Aquaculture Research, 43 (8), 1071-1080. Wiley
Zhang, L., Li, L. & Zhang, G.
Bioinformatics data mining of EST-tandem repeats of the Pacific Oyster (Crassostrea gigas).
Marine Sciences, 35(4), 9-14. MS
2010
Yuan, Z., Zhang, L., & Zhang, G.
Bioinformatics data mining of EST-tandem repeats of the Haliotis discus hannai.
Marine Science Bulletin, 29(1), 59-64.
2008
Zhang, L., Zeng, H., Zhang, J., Ai, Q., & Mai, K.
A study on feeding attraction activity of Chinese herbal medicine for Japanese sea bass Lateolabrax japonicus C.
Marine Fisheries Research, 29(4), 101-105. MFR
2017
Zhang, L., Mazo-Vargas, A. & Reed R.
A single master regulatory gene coordinates the evolution and development of butterfly color and iridescence.
Proceedings of the National Academy of Sciences Cover Article
Mazo-Vargas, A., C. Concha, L. Livraghi, D. Massardo, R. Wallbank, L. Zhang, J. Papador, D. Martinez-Najera, M.R. Kronforst, C.J. Breuker, R. Reed, N.H. Patel, W.O. McMillan, A. Martin.
Macroevolutionary shifts of WntA function potentiate butterfly wing-pattern diversity.
Proceedings of the National Academy of Sciences
Zhang, L.#, Martin, A., Perry, M., van der Burg, K., Matsuoka, Y., Monteiro A.# & Reed R.#
Genetic Basis of melanin pigmentation in butterfly wings.
Genetics, 205(4):1537-1550. Cover Article
Zhang, L., Reed R.
A practical guide to CRISPR/Cas9 genome editing in Lepidoptera.
In Diversity and Evolution of Butterfly Wing Patterns
Li Y., Zhang L., Qu T., Tang X., Li L. & Zhang G.
Conservation and divergence of mitochondrial apoptosis pathway in the Pacific oyster, Crassostrea gigas.
Cell death & disease, 8(7):e2915.
Huang, B*., Zhang, L.*, Du, X., Xu, F., Li, L. & Zhang, G.
Characterization of the Mollusc RIG-I/MAVS Pathway Reveals an Archaic Antiviral Signaling Framework in Invertebrates.
Scientific reports, 7:8217. PubMed
2016
Zhang, L. & Reed R.D.
Key roles for spalt and Distal-less in butterfly eyespot development revealed by CRISPR/Cas9 genome editing.
Nature Communications, 7, 11769. Ncomms
Media coverage: Science News, Science Daily, EurkAlt, Newswise, Technology.org, Health Medicinet, Cornell Chronicle, Gazeta.ru, NU
Huang, B.*, Zhang, L.*, Tang, X., Zhang, G., & Li, L.
Genome-wide analysis of alternative splicing provides insights into stress adaptation of the Pacific oyster.
Marine Biotechnology, 18(5):598-609. Springer
Tang, X., Huang, B., Zhang, L., Li, L., & Zhang, G.
TANK-binding kinase-1 broadly affects oyster immune reponse to bacteria and viruses.
Fish & Shellfish Immunology, 56, 330-335. PubMed
Zhu, Q., Zhang, L., Li, L., Que, H., & Zhang, G.
Expression characterization of stress genes under high and low temperature stresses in the Pacific oyster, Crassostrea gigas.
Marine Biotechnology, 18(2), 176-188. PubMed
Li, Y., Zhang, L., Qu, T., Li, L., & Zhang, G.
Characterization of oyster woltage-dependent anion channel 2 (VDAC2) suggests its involvement in apoptosis and host defense.
PloS one, 11(1), e0146049. PubMed
Huang, B., Zhang, L., Du, Y., Li, L., Tang, X., & Zhang, G.
Molecular characterization and functional analysis of tumor necrosis factor receptor-associated factor 2 in the Pacific oyster.
Fish & Shellfish Immunology, 48, 12-19. PubMed
Zhang, G., Li, L., Meng, J., Qi, H., Qu, T., Xu, F., & Zhang, L.
Molecular basis for adaptation of oysters to stressful marine intertidal environments.
Annual review of animal biosciences, 4, 357-381. PubMed
2015
Meng, J., Zhang, L., Li, L., Li, C., Wang, T., & Zhang, G.
Transcription factor CgMTF-1 regulates CgZnT1 and CgMT expression in Pacific oyster (Crassostrea gigas) under zinc stress.
Aquatic Toxicology, 165,179-188. PubMed
Guo, X., He, Y., Zhang, L., Lelong, C., & Jouaux, A.
Immune and stress response in oysters with insights on adaptation.
Fish & Shellfish immunology, 46(1), 107-119. PubMed
Zhang, L., Li, L., Guo, X., Litman, G. W., Dishaw, L. J., & Zhang, G.
Massive expansion and functional divergence of innate immune genes in a protostome.
Scientific Reports, 5, 8693. PubMed
100 topcited, 2015
Huang, B., Zhang, L., Li, L., Tang, X., & Zhang, G.
Highly diverse fibrinogen-related proteins in the Pacific oyster Crassostrea gigas.
Fish & Shellfish immunology, 43(2), 485-490. PubMed
Qu, T.*, Zhang, L.*, Wang, W., Huang, B., Li, Y., Zhu, Q., & Zhang, G.
Characterization of an inhibitor of apoptosis protein in Crassostrea gigas clarifies its role in apoptosis and immune defense.
Developmental & Comparative Immunology, 51(1), 74-78. PubMed
Meng, J., Zhang, L., Huang, B., Li, L., & Zhang, G.
Comparative analysis of oyster (Crassostrea gigas) immune responses under challenge by different Vibrio strains and conditions.
Molluscan Research, 35(1), 1-11. MR
2014
Zhang, L., Li, L., Zhu, Y., Zhang, G., & Guo, X.
Transcriptome analysis reveals a rich gene set related to innate immunity in the eastern oyster (Crassostrea virginica).
Marine Biotechnology, 16(1),17-33. PubMed
Wang, X., Li, Q., Lian, J., Li, L., Jin, L., Cai, H., Xu F., Qi H., Zhang L.,... & Zhang, G.
Genome-wide and single-base resolution DNA methylomes of the Pacific oyster Crassostrea gigas provide insight into the evolution of invertebrate CpG methylation.
BMC genomics, 15(1), 1119. PubMed
Huang, B., Zhang, L., Du, Y., Li, L., Qu, T., Meng, J., & Zhang, G.
Alternative splicing and immune response of Crassostrea gigas tumor necrosis factor receptor-associated factor 3.
Molecular biology reports, 41(10), 6481-6491. PubMed
Qu, T, Huang, B, Zhang, L., Li, L., Xu, F., Huang, W., Li, C., Du, Y., Zhang, G.
Identification of functional characterization of two executioner caspases in Crassostrea gigas.
PloS one, 9(2),e89040. PubMed
2013
Zhang, L., Li, L., Xu, F., Qi, H., Wang, X. & Zhang, G
Fosmid library construction and microsatellite analysis of the Pacific oyster, Crassostrea gigas.
Molluscan Research, 33(1),65-73. MR
Du, Y., Zhang, L., Xu, F., Huang, B., Li, L. & Zhang, G.
Validation of housekeeping genes as internal controls for studying gene expression during Pacific oyster (Crassostrea gigas) development by quantitative real-time PCR.
Fish & Shellfish Immunology, 34(3),939-945. PubMed
Du, Y., Zhang, L., Huang, B., Li, L. & Zhang, G.
Molecular cloning, characterization and expression of two MyD88s in Pacific oyster (Crassostrea gigas).
Journal of the World Aquaculture society, 44(6), 759-774. Wiley
Meng, J., Zhu, Q., Zhang, L., Li, C., Li, L., She, Z., & Zhang, G.
Genome and transcriptome analyses provide insight into the euryhaline adaptation mechanism of Crassostrea gigas.
PloS one, 8(3), e58563. PubMed
2012
Zhang, G. *, Fang, X. *, Guo, X. *, Li, L. *, Luo, R. *, Xu, F. *, Yang, P. *, Zhang, L. *, Wang, X. *, Qi, H., Xiong, Z., et al.
The oyster genome reveals stress adaptation and complexity of shell formation.
Nature, 490 (7418), 49-54. (* co-first author) Nature
Media coverage: Washington Post, Science News, BBC News, Science Daily, Scientific American, Fox News, Yahoo News
Zhang, L., Li, L. & Zhang, G.
Sequence variability of fibrinogen-related proteins (FREPs) in the Crassostrea gigas.
Chinese Science Bulletin, 57 (25), 3312-3319. Springer
2011
Zhang, L., Li, L. & Zhang, G.
A Crassostrea gigas Toll-like receptor and comparative analysis of TLR pathway in invertebrates.
Fish & Shellfish Immunology, 30, 653-60. PubMed
Zhang, L., Li, L. & Zhang, G.
Gene discovery, comparative analysis and expression profile reveal the complexity of the Crassostrea gigas apoptosis system. Developmental & Comparative Immunology, 35: 603-610. PubMed
Zhang, L., Li, L. & Zhang, G.
The first identification of molluscan Ecsit in the Pacific oyster, Crassostrea gigas, and its expression against bacterial challenge
Aquaculture Research, 43 (8), 1071-1080. Wiley
Zhang, L., Li, L. & Zhang, G.
Bioinformatics data mining of EST-tandem repeats of the Pacific Oyster (Crassostrea gigas).
Marine Sciences, 35(4), 9-14. MS
2010
Yuan, Z., Zhang, L., & Zhang, G.
Bioinformatics data mining of EST-tandem repeats of the Haliotis discus hannai.
Marine Science Bulletin, 29(1), 59-64.
2008
Zhang, L., Zeng, H., Zhang, J., Ai, Q., & Mai, K.
A study on feeding attraction activity of Chinese herbal medicine for Japanese sea bass Lateolabrax japonicus C.
Marine Fisheries Research, 29(4), 101-105. MFR